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Mifepristone–misoprostol vs misoprostol-alone regimen for medication abortion at ≥ 24 weeks’ gestation

Contraception Jun 10, 2020

Wingo E, Raifman S, Landau C, et al. - Via performing a retrospective study of medication abortion at ≥ 24 weeks’ gestation between May 2016 and January 2018 at one site, researchers compared time from misoprostol initiation to fetal expulsion for mifepristone–misoprostol vs misoprostol-alone regimens of medication abortion performed at ≥ 24 weeks’ gestation. They analyzed data from 257 patients in the mifepristone–misoprostol group and 152 patients in the misoprostol-alone group. No association of addition of mifepristone with a reduction in induction interval at ≥ 24 weeks was evident. However, a lower total dose of misoprostol and lower necessity for two days of laminaria were observed among patients in the mifepristone–misoprostol group. These differences may have implications for patient experience. Both the groups had low rates of complications.

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