Hui P, et al. - The differential miRNA signatures for distinguishing high-grade ovarian serous carcinoma from primary endometrial serous carcinoma were determined. A nested cross-validated convergent forest plot was established to classify the tumors with 91.5% accuracy using 6 of 11 miRNA signatures. The characterization of a miRNA signature panel revealed prominent discriminatory power for separating primary ovarian high-grade serous carcinomas from the endometrial counterparts.