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MicroRNA and circular RNA expression in affected skin of patients with postherpetic neuralgia

Journal of Pain Research Oct 26, 2019

Cao S, Zhang D, Yuan J, et al. - Researchers sought to ascertain the mechanisms of postherpetic neuralgia (PHN). They assumed that the initiation and development of this neuropathic pain involve transcripts such as microRNA (miRNA) and circular RNA (circRNA) in the affected skin and hence they sought to report their expression profiles in skins of PHN patients. They applied miRNA and circRNA microarray on the PHN affected skin and the mirror skin and compared their expression profiles. PHN affected skin exhibited 317 differently expressed miRNAs compared with mirror skin (fold change ≥ 2.0), and 13 of them showed fold change > 10 in the PHN skin. They identified only one circRNA, hsa_circRNA_405463 with fold change > 2 in PHN skin, however, there were 31 circRNAs with fold change ≥ 1.5. They examined functions of differential miRNAs via predicting their target mRNAs and conducting bioinformatics analyses including gene ontology, Kyoto Encyclopedia of Genes and Genomes pathway. Target mRNAs significantly enriched in 85 pathways, such as FoxO, AMPK, MAPK and pathway. In this work, for the first time, differential expression of miRNA and circRNA in the PHN skin were reported and these transcripts with abnormal expression are suggested as potential targets to treat PHN.
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