microRNA-944 overexpression is a biomarker for poor prognosis of advanced cervical cancer
BMC Cancer May 10, 2019
Park S, et al. - Using the Kaplan-Meier analysis and Cox proportional hazards model, researchers assessed if miR-944 has any clinical significance or prognostic ability in cervical cancer. For this purpose, they used five types of cervical cancer cell lines and 116 formalin-fixed paraffin-embedded cervical tissues. Cervical cancer tissues vs normal tissues exhibited significantly higher expression levels of miR-944. A marked association of high miR-944 expression with bulky tumor size, advanced International Federation of Gynecology and Obstetrics (FIGO) stage, and lymph node metastasis was evident. Shorter overall survival was observed in the high miR-944 expression group vs low miR-944 expression group in the advanced FIGO stage. For improving prognosis and as a potential therapeutic target, miR-944 may be a new biomarker.
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