Li Y, Huang J, Hu C, et al. - In this study, the role of microRNAs in systemic sclerosis (SSc)-interstitial lung disease (ILD) was investigated. Researchers evaluated miRNA expression patterns by miRNA array and real-time polymerase chain reaction from serum and peripheral blood mononuclear cells of SSc-ILD individuals and healthy controls. They applied the bleomycin-induced SSc-ILD mouse model to confirm the miRNA expression in the lung tissue. miRNA inhibitors, and mimics were applied to evaluate the function of miRNAs in pulmonary fibroblasts. This study’s findings demonstrate that miR-320a, together with its target genes, TGFBR2 and IGF1R, constituted a complex regulatory network, and played an important role in the fibrotic process of SSc-ILD. For SSc-ILD, evaluation of more detailed mechanisms of miR-320a-mediated regulation of collagen expression may provide new therapeutic strategies.