Sadegh Shesh Poli M, et al. - Through nonparametric Spearman’s rho analysis, researchers sought to assess miR146a expression as a prognostic or diagnostic biomarker for esophageal squamous cell carcinoma (ESCC) and also a relationship between miR146a and cyclooxygenase-2 (COX-2) expression. Using real-time–PCR, they quantified the level of miR-146a and COX-2 expression in cancerous and adjacent normal tissue samples obtained from 34 ESCC patients. The outcomes showed a decrease of miR-146a expression in 50% of cancerous tissue when contrasted with adjacent normal regions. Findings suggested that COX2 can be considered a biomarker for diagnosis but miR146a can not be regarded as a biomarker for diagnosis. MiR-146a and COX2 expression will likely be considered as prognostic biomarkers for survival in ESCC.