Wang C, Yang D, Xu C, et al. - Researchers sought to determine how microRNA-139-5p (miR-139-5p) could influence vascular endothelial cells, as well as to identify miR-139-5p expression in acute myocardial infarction (AMI) patients and assess its diagnostic value. To corroborate the interaction of miR-139-5p with vascular endothelial growth factor receptor-1 (VEGFR-1), a dual-luciferase reporter assay was employed. Using Pearson correlation analysis, experts assessed the correlation between miR-139-5p and VEGFR-1. Findings revealed that inhibition of endothelial cell viability of AMI was brought about by miR-139-5p through inhibiting VEGFR-1. The results also demonstrated a high diagnostic value of elevated miR-139-5p expression in AMI patients for the screening of AMI, suggesting a likely role of miR-139-5p as a diagnostic biomarker as well as a molecular treatment target for AMI.