Kao CM, Yee ME, Maillis A, et al. - In this study, the presentation, imaging features, and microbiologic etiologies of children with sickle cell disease (SCD) treated for osteomyelitis (OM) were examined. Researchers carried out to search the comprehensive SCD clinical database of children and adolescents with SCD followed at a single, large tertiary pediatric center to distinguish all diagnostic coding for potential cases of osteomyelitis in children ages 6 months to 21 years from 2010 to 2019. They reviewed medical charts to ascertain OM diagnostic probability based on radiographic and microbiologic findings and the duration of prescribed antibiotic treatment for OM. A review of 3,553 patients (18 039 person‐years) distinguished 20 episodes of probable OM in 19 children. This study's findings demonstrate that the distinction between OM and sickle‐related bone infarct or vasoocclusion is difficult based on imaging findings alone. It was reported that early attainment of blood and operative cultures elevates the likelihood of distinguishing and adequately treating OM.