Macauley M, Adams G, Mackenny P, et al. - Researchers conducted the study for assessing the effect of surgical debridement on the microbiology of resection margins of an infected diabetic foot ulcer and comparing the use of marginal sampling as a guide for antimicrobial therapy. Forty consecutive participants have been investigated. Tissue samples from infected diabetic foot ulcers were collected by podiatrists at first contact. Multiple samples were obtained from the margins of the residuum and also from excised non‐viable tissue after surgical debridement to macroscopically healthy tissue. A relative reduction of 49% was observed in the most pathogenic (red) group of bacteria and 59% in the yellow group in podiatry samples compared with the resection specimen. Positive cultures from marginal tissue samples provided vital information on the presence of pathogenic bacteria after surgical debridement to healthy tissue. This has allowed individualized post-surgical debridement of antibiotics.