Rogeri CD, et al. - Researchers characterized the methylation profile of genes in precursor lesions in cervical cancer to improve screening techniques for high-grade intraepithelial neoplasia. Examination of 447 cervical cytology samples from women who underwent colposcopy was performed and methylation pattern for a panel of 15 genes was analyzed. Findings revealed that in cervical cancer, hypermethylation of the hsa-miR-124-2, SOX1, TERT, and LMX1A genes could be a promising biomarker for precursor lesions, regardless of the hr-HPV status. Methylation of certain genes and hr-HPV infection were noted to have a synergistic effect.