Gerbens LAA, et al. - An inquiry was carried out to examine the long-term effectiveness, safety and drug survival of methotrexate (MTX) and azathioprine (AZA) in severe atopic dermatitis (AD). It was reported that MTX and AZA were possibly effective and safe as maintenance treatments in moderate-to-severe AD up to 5 years. The findings also revealed that few patients in both groups survived on their originally allocated drug. However, some discontinued due to controlled AD.