Platsidaki E, et al. – This trial sought to analyze the clinical efficacy of methotrexate (MTX) as monotherapy in refractory generalized morphea. MTX was found to be an effective and well–tolerated treatment in pediatric patients with morphea. Maximum adult patients exhibited very good and good improvement when treated with MTX. MTX monotherapy was regarded as a safe and effective therapy for the management of this specific clinical subset of morphea in adults.