Han B, Compton WM, Jones CM, et al. - This cross-sectional study revealed a consistent increase in mortality associated with methamphetamine use from 2015 to 2019. During this period, riskier patterns of methamphetamine use were recorded and increased heterogeneity in populations with methamphetamine use disorder risk (particularly those with socioeconomic risk factors and comorbidities) was identified.

• A total of 195,711 respondents to a national survey from 2015 to 2019 were included.

• Increase in methamphetamine use, frequent use, co-use with cocaine, and methamphetamine use disorder occurred 43% to 105%.

• Overall, there was doubling of methamphetamine use disorder without injection and Black individuals showed 10-fold increase in its use.

• Following were the risk factors for methamphetamine use, methamphetamine use disorder, injection, and frequent use: lower educational attainment, lower annual household income, lack of insurance, housing instability, criminal justice involvement, comorbidities (eg, HIV/AIDS, hepatitis B or C virus, depression), suicidal ideation, and polysubstance use.