Tseng CH – Via performing a retrospective cohort analysis, researchers determined the impact of metformin on heart failure in patients with type 2 diabetes. Using data from Taiwan's National Health Insurance database, they analyzed patients with new-onset type 2 diabetes who were followed up from January 1, 2006, to December 31, 2011. Specifically, they assessed an unmatched cohort including 172,542 metformin ever-users and 43,744 never-users, as well as a propensity score matched-pair cohort (matched cohort I: 41,714 ever-users and 41,714 never-users) for the main analyses. In ever-users and never-users, the respective incidence rates of heart failure hospitalization were estimated to be 304.25 and 864.31 per 100,000 person-years in the unmatched cohort, and 469.66 and 817.01 per 100,000 person-years in the matched cohort I. In this study, a lower risk of heart failure hospitalization was evident in relation to metformin use.