Qin W, et al. - The effects of metformin on the proliferation and differentiation of dental pulp cells (DPCs) were investigated in this study. The authors revealed that metformin could induce DPC differentiation and mineralization in an adenosine 5'-monophosphate-activated protein kinase (AMPK)-dependent manner. This (well-tolerated antidiabetic drug) had potential in regenerative endodontics as well as in other regenerative applications.