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Metastasis-directed therapy in treating nodal oligorecurrent prostate cancer: A multi-institutional analysis comparing the outcome and toxicity of stereotactic body radiotherapy and elective nodal radiotherapy

European Urology Jul 26, 2019

De Bleser E, et al. - Researchers sought the relative efficacy and toxicity of stereotactic body radiotherapy (SBRT) vs elective nodal radiotherapy (ENRT) as metastasis-directed treatments in oligorecurrent prostate cancer (PC). In this multi-institutional, retrospective analysis, they included 506 (SBRT: 309, ENRT: 197) patients with hormone-sensitive nodal oligorecurrent PC. Median follow-up of 36 months (interquartile range 23–56) was done. A minimum of 5 Gy per fraction to each lesion with a maximum of 10 fractions, defined SBRT. A minimum dose of 45 Gy in up to 25 fractions to the elective nodes, with or without a simultaneous boost to the suspicious node(s) defined ENRT. As per outcomes, nodal recurrences were less frequent following ENRT vs SBRT, however with higher toxicity. This suggests that the treatment of choice may be elective nodal radiotherapy.

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