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Metastasis-associated protein 1, modulated by miR-30c, promotes endometrial cancer progression through AKT/mTOR/4E-BP1 pathway

Gynecologic Oncology Apr 13, 2019

Xu X, et al. - Researchers examined the link between metastasis-associated protein 1 (MTA1) and endometrial cancer (EC). They analyzed protein expression level of cells and tissues by using Western blot and immunohistochemistry and for RNA detection, they used real-time PCR. They assessed the link between MTA1 and clinicopathological features and survival via bioinformatics tool analysis. They found human EC tissues vs normal endometrium exhibited significantly higher expression level of MTA1. In EC, a positive correlation of MTA1 expression with lymph nodes metastasis and poor survival rate was evident. According to the findings, EC progression might be promoted by MTA1 (as a downstream target of miR-30c) through AKT/mTOR/4E-BP1 pathway, this suggested the potential therapy target of MTA1 in EC.
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