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Metaraminol use during spinal anaesthesia in caesarean sections: A meta-analysis of randomised controlled trials

International Journal of Obstetric Anesthesia Jan 31, 2019

Chao E, et al. - Researchers analyzed randomised controlled trials comparing the use of metaraminol with other vasopressors during spinal anaesthesia at caesarean section. They performed a meta-analysis of 4 good quality randomised, controlled trials that met the selection criteria, with 409 parturients who underwent an elective caesarean section. These studies were identified from PubMed, Cochrane Library, and Embase databases. Findings revealed higher umbilical arterial pH; a lower incidence of fetal acidosis; and a lower incidence of nausea or vomiting observed in association with metaraminol use vs ephedrine use. Higher umbilical arterial pH but a higher incidence of reactive hypertension were observed with metaraminol vs phenylephrine. Overall, metaraminol could be more suitable vasopressor than ephedrine and at least be non-inferior to phenylephrine for use during spinal anaesthesia at elective caesarean section.
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