Choi WR, et al. - Authors analyzed the data to estimate the prognostic role of Fluorine 18-fluorodeoxyglucose positron emission tomography/CT (¹⁸F-FDG PET/CT) parameters quantitatively measured in subjects with recurrent oral cavity cancer. They observed a significant association of ¹⁸F-FDG PET parameters like SUV_max, SUV_mean, SUV_peak, metabolic tumor volume (MTV), and total lesion glycolysis (TLG) with poor progression-free survival (PFS) and overall survival (OS) outcomes after salvage treatment. An association of high MTV (>8.8 mL) or TLG (>29.4 g) values at recurrent lesions with >5-fold increased risk for tumor progression and mortality after salvage surgery was also noted. In multivariate analyses, they suggested Karnofsky performance score, recurrence site, MTV and TLG as independent predictive factors for both PFS and OS.