Gonzalez HM, et al. - This cross-sectional study examined the connections among neurocognitive function, metabolic syndrome (MetS), and inflammation among diverse middle-aged and older Hispanics/Latinos aged 45–74 years. Data unveiled that MetS status correlated with lower global neurocognition, mental status, verbal learning and memory, verbal fluency, and executive function. Age appeared to significantly modify the associations between learning and memory measures and MetS. Yielded findings supported and extended current theories that midlife could present as an especially susceptible developmental period for unhealthy neurocognitive aging.