Zhuang Z, Yu C, Guo Y, et al. - Researchers conducted the study for examining the causal effect of elevated 25(OH)D with the detailed systemic metabolite profile in Chinese adults. In total, 225 lipid and other metabolites were quantified in 4,662 people in China Kadoorie Biobank. Instrumental variable analyses were conducted to test the causal associations of plasma 25(OH)D with the lipids and metabolites. Higher plasma 25(OH)D was associated with favorable lipid profiles in observational analyses. A possible causal association of plasma 25(OH)D with cholesterol, lipoprotein particles, phospholipid concentrations and total lipids within very small VLDL and IDL was indicated by the MR analysis of metabolic data based on a population-based cohort. The results illustrate the long-term impact of 25(OH)D levels in maintaining healthy lipid metabolism.