Kwong SC, et al. - Since growing evidence reveals the influence of deregulated lipid metabolism on cancer cell survival, researchers focused on the function of fatty acid binding protein 7 (FABP7), which is expressed mainly in triple negative breast cancer (TNBC) tissues. In the TNBC cell lines tested, FABP7 was not identified, and therefore, they transduced Hs578T and MDA-MB-231 cells with lentivirus particles comprising either FABP7 open reading frame or red fluorescent protein. Reduction in the viability of Hs578T, but not of MDA-MB-231 cells, was induced by FABP7 during serum starvation with significantly decreased lipids. S/G2 phase arrest and cell death occurred as a result of the failure of FABP7-overexpressing Hs578T cells to efficiently utilize other available bioenergetic substrates such as glucose to sustain ATP generation. In this study, imperative evidence was generated showing metabolic vulnerabilities driven by FABP7 via PPAR-α signalling.