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Metabolic phenotypes of early gestational diabetes mellitus and their association with adverse pregnancy outcomes

Diabetic Medicine Oct 05, 2020

Immanuel J, Simmons D, Harreiter J, et al. - Utilizing data from the Vitamin D And Lifestyle Intervention for gestational diabetes prevention (DALI) trial performed across nine European countries (2012–2014), researchers carried out a post hoc analysis to characterize the metabolic phenotypes of early gestational diabetes mellitus and their correlation with adverse pregnancy outcomes. In women with a BMI ≥ 29 kg/m2), insulin resistance and secretion were measured from the oral glucose tolerance test values conducted before 20 weeks, utilizing homeostatic model assessment of insulin resistance and Stumvoll first‐phase indices, respectively. A higher degree of insulin resistance alone was more likely to be associated with adverse pregnancy outcomes in overweight and obese women with early gestational diabetes than lower insulin secretion alone or a combination of both.

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