Tinius RA, Blankenship MM, Furgal KE, et al. - In this interventional physiology study, researchers contrasted metabolic flexibility between overweight/obese and lean women, as well as determined the connections between metabolic flexibility, inflammation following a high-fat meal, and maternal metabolic health outcomes (ie, gestational weight gain and insulin resistance). This investigation evaluated lipid oxidation rates through indirect calorimetry before and after consumption of a high-fat meal. Sixty-four women who were pregnant (lean = 35, overweight/obese = 29) engaged between 32 and 38 weeks gestation. Overweight and obese pregnant women are less 'metabolically flexible' than lean women and this is due to postprandial inflammation and resistance to insulin.