Wang Q, et al. - Researchers investigated the cross-sectional and longitudinal associations of reproductive status (defined according to the 2012 Stages of Reproductive Aging Workshop criteria) with 74 metabolic biomarkers. They further analyzed whether any associations were independent of age-related changes. They noted effects of the transition to post-menopause on multiple circulating metabolic biomarkers, over and above the underlying age trajectory. The adverse changes in multiple apolipoprotein-B-containing lipoprotein subclasses and increased inflammation could underlie women’s increased cardiometabolic risk in their post-menopausal years.