Hasan LK, Aljabban J, Rohr M, et al. - Researchers conducted this meta analysis with the aim to determine mesenchymal stem cell (MSC) biomarkers in patients with osteoporosis. They herein describe osteoporosis pathogenesis using the Search Tag Analyze Resource for the Gene Expression Omnibus (STARGEO) platform. Fifteen osteoporotic and 14 healthy control MSC samples were compared. They identified very little literature describing the genetic pathways contributing to osteoporosis. Several important genes involved in osteoporosis pathogenesis were identified, which included ESR1, CTNNβ1, CREB1, and ERBB2. Numerous polymorphisms observed in ESR1 may play a prominent role in osteoporosis. This study indicates a prominent role of the Wnt pathway, which includes the CTNNβ1 gene, in bone mass regulation. Polymorphisms in the Wnt pathway can elevate susceptibility to osteoporosis. In addition, this analysis indicates a potential mechanism for ERBB2 in osteoporosis through Semaphorin 4D (SEMA4D). Various genes and pathways identified in this meta analysis can be targeted to develop new anabolic drugs for osteoporosis treatment.