Reynolds IS, et al. - Given that in 5–15 % of colorectal adenocarcinomas, mucinous differentiation occurs that responds poorly to chemoradiotherapy and has a worse prognosis, researchers used meta-analytical techniques to elucidate the molecular associations of mucinous colorectal cancer. Adhering to MOOSE guidelines, they searched databases for studies comparing KRAS, BRAF, microsatellite instability (MSI), CpG island methylator phenotype (CIMP), p53 and p27 status between patients with mucinous and non-mucinous colorectal adenocarcinoma. They included data from 46 studies describing 17,746 patients. BRAF, MSI and CIMP pathways were predominantly correlated to the genetic origins of mucinous colorectal adenocarcinoma. The resistance to standard chemotherapy regimens seen in mucinous adenocarcinoma could be partly explained via this pattern of molecular alterations.