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Meta-analysis of the effect of extending the interval after long-course chemoradiotherapy before surgery in locally advanced rectal cancer

British Journal of Surgery Jul 23, 2019

Ryan EJ, et al. - Given that in locally advanced rectal cancer, total mesorectal excision (TME) is conventionally performed approximately 6–8 weeks after neoadjuvant long-course chemoradiotherapy (nCRT), researchers examined the outcomes following an extension of this interval. They performed a systematic search identifying 26 relevant publications, including four RCTs, with 25,445 patients. The analysis revealed an increase in pathological complete response and downstaging rates and improvement in recurrence-free survival in correlation with a minimum 8-week interval from the end of nCRT to TME. This was evident without compromising surgical morbidity.
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