Meta-analysis of preoperative high-sensitivity cardiac troponin measurement in non-cardiac surgical patients at risk of cardiovascular complications
British Journal of Surgery Jan 14, 2020
Zhao BC, Liu WF, Deng QW, et al. - Researchers here assessed the associations between raised preoperative levels of high-sensitivity troponin and postoperative major adverse cardiac events and/or mortality after non-cardiac surgery in order to determine the prognostic value of high-sensitivity troponin in predicting postoperative outcomes. Searching PubMed, Embase and Science Citation Index Expanded systematically, they included seven cohort studies with a total of 4,836 patients in this work. The analysis revealed elevated preoperative levels of high-sensitivity troponin to be associated with adverse cardiovascular outcomes. Performing high-sensitivity troponin measurement in addition to Lee's Revised Cardiac Risk Index led to an improvement in cardiac risk discrimination quantified by the C-index and risk classification quantified with the continuous net reclassification in the majority of studies. However, the strength of inferences from the findings was weakened by the substantial heterogeneity and inadequate risk stratification analysis.
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