Elgendy IY, et al. - Researchers carried out an updated meta-analysis to assess how intravascular (IVUS)-guided drug-eluting stents (DES) implantation for left main coronary artery (LMCA) impacts individual outcomes measures, given percutaneous coronary intervention with DES has become a reasonable alternative treatment choice to bypass surgery for select patients suffering from unprotected LMCA disease. By analyzing randomized controlled trials in meta-analyses, it has been shown that IVUS-guidance for DES implantation affords a reduction in cardiovascular mortality as well as myocardial infarction; however, LMCA lesions were eliminated from most of these trials. In addition, improved outcomes in relation to IVUS-guided DES implantation to manage LMCA disease were shown in the most recently-published meta-analysis of 4,971 patients with LMCA disease.