Shah T, Haimi I, Yang Y, et al. - Researchers undertook this global meta-analysis to assess gender-based differences in clinical outcomes of ST-segment elevation myocardial infarction (STEMI) as well as to determine the primary driving factors. They analyzed 56 eligible studies comprising 705,098 patients (31% women). Older age, more comorbidities, and receipt of less antiplatelet therapy and primary percutaneous coronary intervention were identified in women. Although STEMI care has improved, females still experience in-hospital rates of mortality, repeat myocardial infarction, stroke, and major bleeding up to 2-fold higher in comparison with males. Age differences at presentation can hugely explain gender discrepancies in in-hospital results but the likely contributors to the gender gap include comorbidities, delays to care and suboptimal treatment experienced by females.