Ejghal R, Charoute H, Talimi H, et al. - A meta-analysis with a total of 1,264 patients and 2,350 controls was performed to determine whether and how TNFα (tumor necrosis factor α)-308G > A polymorphism is related to susceptibility to leishmaniasis. The goal was to draw an overall conclusion using accurate data analysis by increasing the number of cases examined. Findings demonstrated that allele G and allele A of −308G > A polymorphism were not significantly related to leishmaniasis, by taking the two subgroups separately or together. This work insinuates the absence of statistical proof for a link between allele G and allele A of TNFα-308G > A polymorphism and Leishmania infection result. Although a crucial role of TNFα in the immune response against Leishmania infection has been reported but experts inferred that TNFα does not represent the sole determinant factor. TNFα function may be impacted by other factors, such as gene-gene and gene-environment interactions, receptors, and signaling pathway efficiency.