Ando T, et al. - Researchers performed a systematic review and meta-analysis of randomized controlled trials identified via a literature search of PUBMED and EMBASE, to compare the risk of infective endocarditis (IE) between transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR). They calculated the odds ratio (OR) and 95% confidence interval (CI) by using a Mantel-Haenszel method and a random-effects model. Also, based on valve-type (self or balloon-expandable) and surgical risk (high or intermediate), a sub-group analysis was carried out. Overall, they analyzed data from 4 studies with 3,761 (1,895 TAVI and 1,866 SAVR) patients. Findings of this meta-analysis denied an an increased risk of IE in TAVI compared with SAVR. It is essential to implement appropriate preventative measure and early recognition of IE in these cohorts.