Paolucci T, et al. - In view of the possible utility of mesotherapy as an ancillary treatment in the management of localized pain in rehabilitation, researchers conducted a systematic review to appraise new indications for more standard protocols of mesotherapy in rehabilitation. Seven articles (N = 7) that satisfied the inclusion criteria suggested a good efficacy of mesotherapy for acute and chronic musculoskeletal pain. Patients showed good tolerability to the treatment. Investigation for more uniform treatment protocols in future randomized controlled trials is desirable.