Brite J, et al. - Given a positive link between mental health conditions and poor asthma control in the World Trade Center-exposed population, researchers investigated if factors such as medication adherence mediate this link. Adult participants of the World Trade Center Health Registry Cohort who self-reported as asthmatic following the disaster and who were currently prescribed a long-term control medication (LTCM) were examined in this study. Non-adherence to LTCM and poorly or very poorly controlled asthma was reported in 49% and in two thirds, respectively, of the overall study sample of 1,293. A 2-point fall in ACT and half a point reduction in adherence scores was noted in relation to the presence of any mental health condition. However, a statistically significant link of better adherence with slightly worse control was revealed in the multivariable model. The total influence of mental health on asthma control was opposite in sign from the product of the paths between mental health and adherence and adherence and asthma control, and thus, the hypothesis that the negative link between poor mental health and adequate asthma control is mediated by adherence was not supported.