Ezeh U, Ezeh C, Pisarska MD, et al. - In this prospective cross-sectional study, researchers sought to investigate the relation of menstrual cyclicity abnormalities to hyperandrogenism (HA) and dynamic state insulin resistance (IR) in oligo-ovulatory women with polycystic ovary syndrome (PCOS). Fifty-seven women with PCOS (1990 National Institutes of Health criteria) and 57 healthy control women matched by BMI. Compared with oligo-ovulatory eumenorrheic women with PCOS, oligo-ovulatory women with PCOS and overt oligo/amenorrhea have greater degrees of IR but not HA, indicating that IR and hyperinsulinemia but not HA play a role in assessing the degree of menstrual dysfunction, which can be used as a clinical marker for the degree of IR in oligo-ovulatory PCOS.