Bjørnerem A, et al. - The proposition explored herein was that most menopause-related bone loss and changes in bone microstructure were cortical, not trabecular in origin, and were due to intracortical remodeling. No prominent bone loss was brought to light prior to menopause regardless of the microarchitectural changes. The data illustrated the occurrence of over 90% of appendicular bone loss during and after menopause. Among these, over 80% were found to be cortical, thereby elucidating why 80% of fractures were appendicular.