Ference BA, et al. - In this study, 654,783 candidates were analyzed to assess the consequences of genetic inhibition of ATP citrate lyase (ACLY) and to examine its impact on low-density lipoprotein (LDL) cholesterol level. An association of ACLY and 3-hydroxy-3-methylglutaryl–coenzyme A reductase (HMGCR) scores with comparable patterns of variations in plasma lipid and lipoprotein levels was noted. They also found a relationship with similar consequences on the risk of cardiovascular events per decrease of 10 mg per deciliter in the LDL cholesterol level with odds ratio for cardiovascular events, 0.823 for the ACLY score and 0.836 for the HMGCR score. No relation was reported between lifelong genetic inhibition of ATP citrate lyase, as well as lifelong genetic inhibition of HMGCR, and a higher risk of cancer.