Heida EJE, et al. - Neuro-MRI scans, done in a general hospital setting following administration of melatonin in 64 children aged 10 months–5 years, were retrospectively reevaluated by an experienced pediatric neuroradiologist, ranking them as diagnostically contributing or as failed, in order to assess efficiency of melatonin during a daily scanning programme and to estimate its financial advantage. In infants and young children, the use of melatonin in neuropediatric MRI during a daily scanning programme with a remote waiting room, was related to a great success rate. A minority of scans had no movement artefacts, designating most children were not asleep. The sleep-inducing impact of melatonin could hence not be determined, although the high success rate could be assigned to the sedative and/or anxiolytic impact of melatonin. Moreover, only a minority of scans had to be done again under general anesthesia, resulting in a decrease of scan related costs.