Mediation effect of obesity on the association between triglyceride-glucose index and hyperuricemia in Chinese hypertension adults
The Journal of Clinical Hypertension Dec 17, 2021
Sun J, Sun M, Su Y, et al. - In this Han Chinese population, a significant association of the triglyceride glucose (TyG) index with hyperuricemia was evident in patients with hypertension, and obesity had a partial mediation role in this association.
In this community-based cross-sectional study, a total of 4,551 hypertension patients aged 40–75 years with clinical and biochemical data were included.
Patients with hyperuricemia had higher TyG index than those without (8.99±0.61, 8.70±0.59).
In those with the lowest (≤8.32), second (8.33–8.66), third (8.67–9.07) and the highest quartile (≥9.08) of the TyG index, hyperuricemia prevalence was noted to be 6.0%, 10.4%, 15.4%, 21.4%, respectively.
An elevated risk of hyperuricemia was observed in relation to the higher quartile of TyG index, in logistic regression analysis, whether in crude or adjusted models.
The link between the TyG index and hyperuricemia was partially mediated, to some extent, by all of the obesity indexes.
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