Wang A, Tian X, Zuo Y, et al. - In this investigation involving 15,297 candidates, experts aspired to explore whether the impact of ideal cardiovascular health (CVH) metrics on stroke was mediated and enhanced by arterial stiffness. The brachial-ankle pulse wave velocity (baPWV) was used to determine arterial stiffness. There were 324 total stroke events (292 ischemic stroke and 31 hemorrhagic stroke) after a median follow-up of 5.88 years. Arterial stiffness acted as a moderator in the relationships between ideal CVH metrics and the risk of total and ischemic stroke. The combination of ideal CVH metrics and baPWV is a reasonable and useful tool for stroke assessment and prevention.