Picco L, et al. - This research ascertained if self-stigma mediated the link between perceived stigma and quality of life, self-esteem and general functioning among outpatients with depression, schizophrenia, anxiety and obsessive-compulsive disorder (OCD). The mediating effects were found to be evident and varied across diagnoses. Interventions were warranted in order to address and reduce the effects of self-stigma along with targeted therapies and psychoeducation. This would aid the people with mental illness to overcome or better manage self-stigma while providing them the skills to counteract public stigma.