Bedet A, et al. - Experts in a prospective, observational study assessed the factors related to thrombocytopenia during human septic shock. They used a multiplex analysis to evaluate the role of endogenous sepsis mediators. Results demonstrated the involvement of multiple mechanisms in thrombocytopenia during septic shock, including endothelial dysfunction/coagulopathy, hemodilution, and altered thrombopoiesis. Authors noted an association of surrogates of hemodilution (e.g., hypoprotidemia and higher fluid balance) with thrombocytopenia.