Navi BB, Sherman CP, Genova R, et al. - This prospective cross-sectional study was undertaken to analyze the pathophysiology of ischemic stroke with cancer. Researchers enrolled three groups of 50 adult participants each. This study involved a main group comprising patients with active solid tumor cancer and acute ischemic stroke, as well as control groups consisting of patients suffering from acute ischemic stroke only or active cancer only. Univariate between-group comparisons showed that patients with cancer-plus-stroke exhibited higher levels of D-dimer, soluble intercellular adhesion molecule-1, soluble vascular cell adhesion molecule-1, and thrombomodulin vs both control groups; higher concentrations of thrombin-antithrombin relative to cancer-only patients; and higher levels of P-selectin when compared with stroke-only participants. Similar results were obtained in multivariable analyses. Overall, higher markers of coagulation, platelet, and endothelial dysfunction, as well as more circulating microemboli were found in patients with cancer-related stroke vs matched controls.