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Mechanisms of action of a carbohydrate-reduced, high-protein diet in reducing the risk of postprandial hypoglycemia after Roux-en-Y gastric bypass surgery

American Journal of Clinical Nutrition Jan 16, 2019

Kandel D, et al. - In this study, authors assessed 10 patients to compare the acute consequences of a conventionally recommended (CR) diet vs a carbohydrate-reduced, high-protein (CRHP) diet in Roux-en-Y gastric bypass (RYGB) cases. They observed a significant reduction in peak plasma glucose (PG) on the CRHP diet following breakfast and lunch by 11% and 31%, respectively. They noted a decline in insulin secretion and an increase in glucagon secretion on the CRHP diet after both meals. They also recorded no changes in glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide secretion after breakfast on CRHP but a drop was observed after lunch. They determined a decreased glucose variability and lower risk of postprandial hypoglycemia in these candidates with the CRHP diet.

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