Mechanical and oral antibiotic bowel preparation vs no bowel preparation for elective colectomy (MOBILE): A multicentre, randomized, parallel, single-blinded trial
The Lancet Aug 15, 2019
Koskenvuo L, Lehtonen T, Koskensalo S, et al. - Through a multicentre, parallel, single-blinded trial of 738 patients who were undergoing colon resection, researchers examined the recommendation of routine use of mechanical and oral antibiotic bowel preparation (MOABP) in a prospective randomized context. In 13 of 196 and 21 of 200 patients randomized to MOABP and to no bowel preparation (NBP), respectively, surgical site infections (SSI) was detected. In 7 of 196and 8 of 200 patients in the MOABP group and the NBP group, respectively, Anastomotic dehiscence was listed and when compared with 13 of 200 patients, reoperations were necessary for 16 of 196. Two in the NBP group and none in the MOABP group died within 30 days. Therefore, in comparison with NBP, MOABP does not decrease SSIs or the overall morbidity of colon surgery. Thus, the prevailing recommendations of using MOABP for colectomies to diminish SSIs or morbidity should be reviewed.
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