Koskenvuo L, Lehtonen T, Koskensalo S, et al. - The recommendation of routine use of mechanical and oral antibiotic bowel preparation (MOABP) in patients undergoing colon resection was investigated in a prospective randomized context. Researchers conducted this multicentre, parallel, single-blinded trial randomizing (1:1) 417 patients undergoing colon resection to either MOABP or no bowel preparation (NBP) in four hospitals in Finland; 209 were randomized to MOABP and 208 to NBP. For bowel preparation, patients allocated to MOABP drank 2 L of polyethylene glycol and 1 L of clear fluid before 6 pm on the day before surgery and took 2 g of neomycin orally at 7 pm and 2 g of metronidazole orally at 11 pm the day before surgery. Outcomes suggest that MOABP vs NBP leads to no reduction in surgical site infections (SSIs) or the overall morbidity of colon surgery. Hence, they recommend reconsidering the current recommendations of using MOABP for colectomies to reduce SSIs or morbidity.