Dung NH, et al. - Using serum β2-M level on predicting long-term mortality of hemodialysis subjects, 326 prevalent hemodialysis patients were assessed by the researchers in order to measure serum beta2-microglobulin (β2-M, a middle-molecular-weight protein with 11,800 Dal, which is made by all cells expressing the major histocompatibility class I and acknowledged as a surrogate marker relating to the mechanisms of dialysis-associated amyloidosis) for the prediction of long-term mortality using low-flux dialyzer reuse. According to their serum β2-M levels, patients were randomized into group A (n=109), group B (n=109) and group C (n=108). Seventy-five all-cause deaths were observed during the follow-up period of 5 years. In comparison with the lower β2-M groups, Kaplan–Meier analysis exhibited that all-cause mortality in the higher β2-M group was significantly greater. Serum β2-M level was ascertained as an important predictor for all-cause mortality. Hence, in hemodialysis patients, serum β2-M levels were a significant predictor of long-term mortality, who used only low-flux dialyzers and reused 6 times.