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Maximizing cancer prevention through genetic navigation for Lynch syndrome detection in women with newly diagnosed endometrial and nonserous/nonmucinous epithelial ovarian cancer

Cancer May 28, 2021

Kim SR, Tone A, Kim RH, et al. - A comprehensive genetic navigation program was implemented by researchers to elevate the uptake of genetic testing for Lynch syndrome (LS) in patients suffering from endometrial cancer (EC) or nonserous/nonmucinous ovarian cancer (OC). Herein, they prospectively assessed and ascertained if the program could accomplish this goal. In this study, patients with newly diagnosed EC or OC were selected prospectively from 3 cancer centers in Ontario, Canada. This study sample comprised 841 participants (642 with EC, 172 with OC, and 27 with synchronous EC/OC), 194 (23%) were mismatch repair‐deficient by immunohistochemistry. As per findings, a high rate of genetic assessment (>90%), in patients with gynecologic cancer at risk for LS, was obtained after introduction of a navigated genetic program.

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