Hyde NK, et al. – The purpose of this study was to determine the association between maternal vitamin D (25(OH)D) in pregnancy and offspring trabecular bone score (TBS). Available evidence indicated that maternal 25(OH)D in early pregnancy might be associated with TBS in offspring at age 11 in boys. However, further confirmation with larger interventional and long–term follow–up studies was required.

Methods

• From the Vitamin D in Pregnancy (VIP) study data were accumulated.
• At recruitment and at 28–32 weeks’ gestation, venous blood samples were collected.
• With radioimmunoassay, maternal 25(OH)D was analyzed.
• Offspring (n = 195, n = 181 with complete measures) underwent spine DXA (GE Lunar), at age 11 years (median = 10.9 (IQR 10.9–11.4)).
• With the aid of TBS iNsight software, TBS was calculated.

Results

• Results showed that offspring of mothers with sufficient 25(OH)D levels (≥50 nmol/L) at recruitment had a higher TBS (1.363 vs. 1.340, p = 0.04).
• In multivariable linear regression models, after adjustment for child relative lean mass, sex and pubertal stage, a 10 nmol/L increase in maternal 25(OH)D was associated with a 0.005 (95% CI 0.000, 0.010, p = 0.04) increase in TBS.
• However when stratified by sex (p for interaction = 0.16), the association was significant in boys, but not girls.
• No associations were observed with TBS and maternal 25(OH)D at 28–32 weeks.